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SGS has developed an enantioselective approach for plant protection product (PPP) residue studies in response to publication in August of a European Food Safety Authority (EFSA) technical guidance report 10.2903/j.efsa.2019.580.

Enantioselective graph

EFSA’s report is based on risk assessments of active substances in PPP that have enantiomers or stereoisomers as components or impurities, and for transformation products of active substances that may have enantiomers or stereoisomers. Some pesticides are used as racemate mixture (normally comprised of equimolar amounts of isomers) but some other commercial formulations contain only one isomer as an active ingredient. For these formulations, information on the behavior of isomers during the plant metabolization phase is necessary.

SGS has developed an enantioselective technique for residue studies using chiral active ingredients in PPP. At the same time as good laboratory practice (GLP) residue studies, this approach can prove that there is no enantiomeric conversion during the metabolization phase in crops.

With its field station network, SGS is able to conduct field trials on crops applying a formulation containing an isomeric form. Specimens are collected and the residues are analyzed in an SGS laboratory using a non-enantioselective method. Then positive specimens at harvest stages are assessed using an enantioselective method to separate isomeric forms. To get the initial picture of residue’s isomeric form, the tested formulation applied during the field trials can also be analyzed using the enantioselective method.

SGS offers an integrated solution in study management, global GLP field trials and analytical services using consistent tools and approaches. With many years of experience, the SGS team has developed and refined this enantioselective approach and are also able to offer personalized study designs.

For further information, please contact:

Paul Garrigue
GLP Manager/Study Director
t: +33 6 10 86 86 24

About SGS

SGS is the world’s leading inspection, verification, testing and certification company. SGS is recognized as the global benchmark for quality and integrity. With more than 94,000 employees, SGS operates a network of over 2,600 offices and laboratories around the world.