SGS Introduces New Bio-Layer Interferometry Analysis for Biopharmaceutical Development
SGS, a leading bio/pharmaceutical analytical and bioanalytical contract solutions provider, today announced that it is introducing bio-layer interferometry (BLI) for the analysis of molecular interactions in real time, at its laboratory in Mississauga, Canada. This new service leverages the capabilities of the Octet Red96 System to detect specific interactions between a biosensor and a target analyte, and offers a number of advantages over current analytical techniques.
BLI utilizes the principle of optical interferometry to generate real time binding curves. An optic fiber is coated with a specific capture molecule, such as a monoclonal antibody, and binding of a target analyte to the biosensor is monitored using an algorithm which then converts interference patterns into a binding curve. This method can be used to study interactions between most types of molecules, such as protein-protein, protein-small molecule, antibody-peptide, DNA-protein or DNA-DNA. The data generated by the newly installed instrument is 21 CFR part 11 compliant to ensure integrity of information for regulatory submissions.
“BLI is a strong addition to the existing services that SGS offers for protein quantitation, molecular binding affinity and kinetic analysis,” commented Mike Lindsay, Vice President Life Sciences, SGS Canada. “This new technique enhances our ability to offer more robust, high-throughput, cost efficient and complete solutions to assist with candidate selection and assist in the drug-to-market process.”
In comparison with other techniques, BLI is easier to use, more cost effective and more tolerant of samples in complex mixtures, such as media and lysates. For molecular binding affinity/kinetics analysis, BLI provides rate and affinity constants in minutes, allowing for a high throughput method with small volumes. Additionally, protein quantitation can be performed over a large dynamic range (ng/mL to mg/mL), and samples do not need to be purified or diluted, reducing handling and assay time, and enhancing the accuracy of results. Furthermore, the BLI method conserves valuable samples as it is label-free and non-destructive.
The investment in BLI at its Mississauga facility comes after the December 2015 announcement of the acquisition of Quality Compliance Laboratories Inc., which expanded SGS’s comprehensive service provision in the analytical testing of pharmaceutical and biopharmaceutical products, raw materials and packaging, and medical devices capacity from its three laboratories in Canada.
With 20 laboratories offering contract analytical and bioanalytical services, SGS leverages its wholly-owned global network, present in North America, Europe, and Asia, to deliver harmonized solutions to large pharmaceutical and biotechnology firms. In addition to testing services for the bio/pharmaceutical market, SGS also provides Phase I-IV clinical trial management, and services encompassing data management and statistics, PK/PD modeling and simulation, pharmacovigilance and regulatory consultancy.
For further information, please contact:
Life Sciences – Global Marketing Director
Agriculture, Food and Life
SGS, 75 Passaic Avenue, Fairfield, NJ 07004, USA
t: +44 (0)161 728 5880
SGS is the world’s leading inspection, verification, testing and Certification Company. SGS is recognized as the global benchmark for quality and integrity. With more than 85,000 employees, SGS operates a network of over 1,800 offices and laboratories around the world.