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SGS will be participating in the Euro Bioanalysis Forum’s 8th Open Symposium. The Euro Bioanalysis Forum (EBF) organizes annual symposia for the bioanalytical community to discuss challenging procedures and techniques as well as new regulatory requirements.

Starts

November 18, 2015

Ends

November 20, 2015

Location

Barcelona, Spain

For this year's symposium, 5 major themes have been identified which should inspire the attendees to explore, learn and apply. Those 5 majors themes are:

  • Using LC-MS and LBA in synergy
  • Into New Territories  - Technology
  • Into New Territories - Regulations and emerging markets
  • Biomarkers - Suggested session topics
  • What keeps you busy on a daily basis

Join SGS experts at Booth 35 to discuss your future project, and also as they present and discuss six various scientific posters:

  1. Adapting an existing LC-MS/MS assay to accommodate capillary microsampling (CMS)
    Peter Fordham and Bernadette Dupraz
    SGS Life Science Services, Poitiers – France

    Abstract:

    An existing LC-MS/MS assay was adapted so that CMS could be used to reduce the assay volume. The step-by-step approach used to achieve this objective and the results obtained are discussed and presented.

  2. A validated LC-MS/MS assay for the simultaneous quantification of cGMP and cAMP in human plasma
    Nathalie Plaud, Geoffrey Nibaudeau, Nicolas Fourrier and Alain Renoux
    SGS Life Science Services, Poitiers – France

    Abstract: 

    cAMP and cGMP are important second messengers and monitoring their concentrations is a useful means of evaluating the efficacy of phosphodiesterase inhibitor drugs. With this objective in mind, we set out to develop and validate an LC-MS/MS method for simultaneous quantification of cGMP and cAMP in human plasma.

  3. Analytical validation of a 10-plex immunoassay for the determination of IFN-γ, IL-1β, IL-10, IL-12p70, IL-13, IL-2, IL-4, IL-6, IL-8 and TNF-α onto the Meso Scale Discovery platform in human plasma and human serum.
    Sébastien Melin, Hélène Chauvet, Sophie Landriaud, Alain Renoux, Rabia Hidi and Nicolas Fourrier- SGS Life Science Services, Poitiers – France

    Abstract:

    Cytokine assays can be used in the monitoring of immune response following drug administration and can help elucidating mechanism of action of drug therapeutics. Robust and sensitive cytokine immunoassays are required especially when these are used as safety biomarkers. We had fully assessed the analytical performance of a 10-plex (V-plex version) immunoassay from MSD for the determination of IFN-γ, IL-1β, IL-10, IL-12p70, IL-13, IL-2, IL-4, IL-6, IL-8 and TNF-α concentrations in human serum and human plasma. This new assay version offers good lot-to-lot reproducibility with consistent results across batches.

  4. Analytical validation of a 10-plex immunoassay for the determination of Eotaxin, MIP-1β, Eotaxin-3, TARC, IP-10, MIP-1α, IL-8, MCP-1, MDC AND MCP-4 onto the Meso Scale Discovery platform in human serum.
    Emilie Stéphan, Karine Pardon, Sébastien Melin, Alain Renoux, Rabia Hidi and Nicolas Fourrier
    SGS Life Science Services, Poitiers – France

    Abstract:

    Chemokine assays can be used in the monitoring of immune response following drug administration and can help to elucidate mechanism of action of drug therapeutics. Robust and sensitive immunoassays are required especially when these are used as safety biomarkers.
    We had validated a 10-plex (V-plex version) immunoassay from MSD for the quantification of Eotaxin, MIP-1β, Eotaxin-3, TARC, IP-10, MIP-1α, IL-8, MCP-1, MDC AND MCP-4. This new assay version offer good lot-to-lot reproducibility with consistent results across batches.

  5. Immunogenicity assessment using the Watson Immune Response Module From Thermo Scientific.
    Emmanuel Guignouard, Eric Flajoulot, Alain Renoux, Rabia Hidi and Nicolas Fourrier
    SGS Life Science Services, Poitiers – France

    Abstract: 

    The administration of biotherapeutics can lead to unwanted immunogenicity response. Anti-Drug Antibody response is an important parameters of biologic drug safety studies. Immunogenicity assessment is therefore part of biologics development programme. ADA testing follows a tiered approach which includes screening, confirmatory and titration assays. Beside tiered approach characterisation of ADA such as neutralising activity can be evaluated. A tool for the assessment of ADA response was developed by Thermo Scientific. This tool allows bioanalytical data management in immunogenicity studies. This module is fully integrated into the Watson LIMS and was validated for its use in GLP/GCP compliant bioanalytical studies. The poster highlights the key features of the Immune Response Module and discusses its limitations particularly for the analytical validation of immunogenicity assays.

  6. LC/MS-MS methods for the determination of goserelin in lithium heparinised human plasma
    Sandrine Coppee, Sophie Minet, Coralie Quinet, Romuald Sable, Bernard Jeanbaptiste
    SGS Life Science Services, Wavre – Belgium

    Abstract: 

    Purpose: A LCMSMS method validation of a selective method for the determination of goserelin in human plasma. Goserelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). It decreases the production of estrogen and testosterone and is used in combination with radiation therapy to treat cancers of the breast in women and the prostate in men. 
    Conclusion: This method allows sensitive determination of goserelin in human plasma in the range of 50 to 25000 pg/mL. Complementary selective methods for the determination of estradiol and testosterone in human plasma were also available.

For more information, please go on the European Bioanalysis Forum Website.