Email this pageEmail this pagePrint this pagePrint this page
Share on LinkedInShare on LinkedInShare on FacebookShare on FacebookTweet thisTweet this

Life Sciences

Categories

Minimize menuMaximize menu

Minimize menuMaximize menuHomeLife SciencesHealth, Beauty & WellnessNutraceuticals & Dietary SupplementsLaboratory ServicesCell-Based Assays

Related Services & Resources

Cell-Based Assays

SGS scientists can carry out the development of in vitro assays on your behalf such as CACO2, and skin permeability models. We also have flow cytometry capabilities in our own laboratories.

Our experts are highly experienced in both implementing client assays and developing them de novo. Our laboratories in France and Belgium are both GLP-certified and routine audits from the local agencies have proved that our laboratories consistently attain the highest standards in GLP compliance. In these facilities, we provide bioanalytical support for approximately 100 pre-clinical studies per year.

Our In Vitro Assay Service and Cell-based Bioassays Services include:

    Models:

  • Monolayers: Customized sourcing of primary fibroblast or keratinocyte cultures
  • Human and animal cell lines (L929, Vero, IMR-90, MRC-5, CHO, HL-60, etc.)
  • 3D skin model (epidermis – full thickness)
  • 3D human corneal epithelium
  • 3D human lung epithelium model
  • CACO-2 (human small intestine model)
  • Isolated human blood cells (PBMC, lymphocytes, monocytes, etc.)

     Study types:

  • Barrier and metabolic functionalities as in vivo
  • Percutaneous absorption and metabolism, skin irritation, sensitization, corrosivity tests, phototoxicity, wound healing
  • Prediction of eye irritation potential of chemicals (alternative for in vivo Draize test)
  • Intestinal absorption and metabolism
  • Medical device cytotoxicity
  • Permeability of drug substances
  • Toxicity of API or excipients
  • API receptor binding assays
  • Wound healing
  • Physiological effect on cell cultures 
  • Biomarkers synthesis and release
  • Bioassays for neutralizing antibodies
  • Cytokine production
  • Phagocytosis/Opsonization
  • Study of Intracellular Enzyme Activity (COX, MPO, etc.)
  • Study of Signal transduction (STAT-1, p38 MAPK,P44, AKT/PKB, etc.)
  • Immune cell activation and toxicity study types:
    • Biomarkers (cell receptor activation & signaling)
    • Phagoctosis of neutrophiles/macrophage
    • Opsonization
    • Phototoxicity
  • Flow cytometry: BD FACSCanto II (Immunophenotyping/Immunotox)
  • Immunogenicity of vaccines
  • Cell-mediated immunity
Email Us
Lab ServicesLaboratory Services by SGSA comprehensive look at SGS’s global lab services (PDF 1,4MB) ...
Bioanalytical ServicesBioanalytical Services by SGSBioanalysis testing from early to late phase (PDF 92KB) ...
Interactive Pocket MapLife Science Services & Sites Pocket MapA quick reference to our global sites and services. ...

Contact

SGS Headquarters

  • 1 Place des Alpes
  • P.O. Box 2152
  • Geneva, 1211
  • Switzerland
  • t   +41 22 739 91 11
  • f   +41 22 739 98 86
  • e   Email Us

E-SUBSCRIPTIONS

Sign up to SGS publications and newsletters from your region and around the world
STAY UP TO DATE.SUBSCRIBE NOW

Office Directory

Find SGS offices and labs around the world.World map
Office Locator

News

events